Wrinkle Reduction/Neuromodulator Injections

Cosmetic neuromodulators are injectable treatments that help relax the facial muscles that cause expression lines. By reducing or eliminating muscle movement, they soften the appearance of wrinkles like frown lines, crows feet, and forehead lines. The result is smoother, more refreshed-looking skin. Patients also appreciate the avoidance of looking angry or tired.

ENT Associates of Fresno is proud to offer two brands of neuromodulators –

Jeuveau® and Botox®. Both are FDA-approved treatments for the reduction of vertical “11 lines” that form between the eyebrows, and are widely used to reduce a variety of other facial and neck wrinkles and signs of aging.

Jeuveau® and Botox®: Modern Solutions for Smoother, Youthful-Looking Skin


Botox® was the first neuromodulator to be used for cosmetic purposes, while Jeuveau® (sometimes called “Newtox”) is one of the newest FDA-approved injectable treatments designed specifically to soften wrinkles. These products work in a similar manner to minimize facial expression lines that become more noticeable over time due to repeated facial expressions like frowning, squinting, or concentrating.

How Neuromodulators Work

Jeuveau® and Botox® are made from a purified form of botulinum toxin type A. When injected into targeted facial muscles:

  • They temporarily reduce muscle activity, preventing the repeated movements that deepen wrinkles.
  • The overlying skin gradually smooths, creating a softer, more relaxed appearance.
  • The dose is carefully tailored to your facial anatomy so your expressions still look natural—not frozen.

Most patients begin noticing improvement within 2–4 days, with full results visible around 1–2 weeks.

Your Treatment Experience

Before Your Appointment

You will discuss all of your concerns, review your facial anatomy, and create a customized treatment plan.

During the Appointment

  • The procedure typically takes 10 minutes or less.
  • A series of small injections is placed precisely into the muscles that cause facial lines of expression.
  • Most patients describe the sensation as a quick pinch.

After Your Appointment

  • You can return to most normal activities right away.
  • Mild redness or small bumps may appear temporarily and usually fade within minutes to hours.
  • Your results will gradually develop over the next few days.

How Long Results Last

Jeuveau® and Botox® results generally last 3–4 months, though some patients may notice longer or shorter durations depending on:

  • Their muscle strength
  • Their metabolism
  • How expressive they naturally are
  • Their treatment history

Routine treatments help maintain a smoother look year-round.

Safety & Possible Side Effects

Jeuveau® and Botox® are FDA-approved and considered safe when administered by a trained provider. Possible temporary side effects may include:

  • Slight swelling or redness at the injection sites
  • Mild tenderness
  • Small bruising
  • Headache or a feeling of heaviness

These effects typically resolve on their own. All safety information will be reviewed with you before treatment.

Why Patients Choose Neuromodulator Treatments

  • Noticeably smoother frown lines
  • Quick appointments with little to no downtime
  • Natural results that still allow facial expression
  • A modern, highly refined neuromodulator option
  • Ideal for both first-time and experienced patients

Are Jeuveau® and Botox® Right for You?


If you’re looking to reduce frown lines and achieve a refreshed, more youthful look without surgery, these neuromodulators may be an excellent option. They are suitable for adults of all ages who want subtle, natural enhancement and a smoother, brighter appearance.